The 49ers opened as moneyline favorites and are priced at around -120 heading into the Big Game.
The odds depend on the sportsbook.
San Francisco, favored by just two points, has not won a Super Bowl since 1995, losing its last two appearances, including against Kansas City in 2020.
This is the first Super Bowl appearance for San Francisco quarterback Brock Purdy, who is only two years removed from being the last pick in the 2022 NFL Draft.
That hasn’t stopped him from going 21-5 as a starter in his career, including 4-1 in the playoffs. 49ers head coach Kyle Shanahan is also searching for his first Super Bowl title.
That may prove difficult against Patrick Mahomes and Andy Reid, as the duo are close to unbeatable in the playoffs. Mahomes is 14-3 in the postseason, ranking behind Tom Brady and Joe Montana for most postseason wins by a QB.
With 25 postseason wins, Reid trails only Bill Belichick (31).
Kansas City has the momentum after rattling off five straight wins and is playing its best football of the year. San Francisco has looked discombobulated in recent games.